| East Islip to Olympia Heights (Florida) | 1,114.87 mi (1,794.21 km) |
| East Islip to Omaha (Nebraska) | 1,189.59 mi (1,914.46 km) |
| East Islip to On Top of the World Designated Place (Florida) | 952.86 mi (1,533.48 km) |
| East Islip to Onalaska (Wisconsin) | 944.31 mi (1,519.72 km) |
| East Islip to Oneida (New York) | 206.36 mi (332.11 km) |
| East Islip to Oneonta (New York) | 153.98 mi (247.81 km) |
| East Islip to Ontario (California) | 2,455.37 mi (3,951.53 km) |
| East Islip to Ontario (Oregon) | 2,220.30 mi (3,573.23 km) |
| East Islip to Opa-locka (Florida) | 1,101.68 mi (1,772.99 km) |
| East Islip to Opelika (Alabama) | 874.04 mi (1,406.63 km) |
| East Islip to Opelousas (Louisiana) | 1,269.54 mi (2,043.13 km) |
| East Islip to Orange (California) | 2,473.32 mi (3,980.42 km) |
| East Islip to Orange (Texas) | 1,365.27 mi (2,197.19 km) |
| East Islip to Orange City (Florida) | 934.26 mi (1,503.55 km) |
| East Islip to Orangeburg (South Carolina) | 654.28 mi (1,052.97 km) |
