| East Islip to Enumclaw (Washington) | 2,427.15 mi (3,906.13 km) |
| East Islip to Ephrata (Pennsylvania) | 161.85 mi (260.48 km) |
| East Islip to Erie (Colorado) | 1,667.87 mi (2,684.17 km) |
| East Islip to Erie (Pennsylvania) | 369.39 mi (594.47 km) |
| East Islip to Erlanger (Kentucky) | 615.55 mi (990.63 km) |
| East Islip to Escanaba (Michigan) | 779.67 mi (1,254.76 km) |
| East Islip to Escondido (California) | 2,453.54 mi (3,948.59 km) |
| East Islip to Española (New Mexico) | 1,800.08 mi (2,896.96 km) |
| East Islip to Essex (Maryland) | 198.47 mi (319.41 km) |
| East Islip to Essex Junction (Vermont) | 260.13 mi (418.64 km) |
| East Islip to Estelle (Louisiana) | 1,210.90 mi (1,948.75 km) |
| East Islip to Estero (Florida) | 1,103.81 mi (1,776.41 km) |
| East Islip to Euclid (Ohio) | 437.35 mi (703.84 km) |
| East Islip to Eufaula (Alabama) | 900.96 mi (1,449.95 km) |
| East Islip to Eugene (Oregon) | 2,519.16 mi (4,054.20 km) |
