| East Chicago to Southern Pines (North Carolina) | 622.97 mi (1,002.57 km) |
| East Chicago to Southfield (Michigan) | 222.62 mi (358.27 km) |
| East Chicago to Southgate (Michigan) | 221.76 mi (356.89 km) |
| East Chicago to Southlake (Texas) | 801.83 mi (1,290.43 km) |
| East Chicago to Spanaway (Washington) | 1,752.15 mi (2,819.81 km) |
| East Chicago to Spanish Fork (Utah) | 1,263.80 mi (2,033.89 km) |
| East Chicago to Spanish Lake (Missouri) | 245.14 mi (394.51 km) |
| East Chicago to Spanish Springs (Nevada) | 1,684.45 mi (2,710.86 km) |
| East Chicago to Sparks (Nevada) | 1,688.36 mi (2,717.16 km) |
| East Chicago to Spartanburg (South Carolina) | 551.41 mi (887.41 km) |
| East Chicago to Spearfish (South Dakota) | 847.30 mi (1,363.60 km) |
| East Chicago to Speedway (Indiana) | 142.78 mi (229.78 km) |
| East Chicago to Spencer (Iowa) | 406.11 mi (653.57 km) |
| East Chicago to Spokane (Washington) | 1,520.31 mi (2,446.70 km) |
| East Chicago to Spokane Valley (Washington) | 1,511.08 mi (2,431.86 km) |
