| East Chicago to Scottsboro (Alabama) | 489.84 mi (788.31 km) |
| East Chicago to Scottsdale (Arizona) | 1,437.61 mi (2,313.61 km) |
| East Chicago to Scranton (Pennsylvania) | 609.60 mi (981.06 km) |
| East Chicago to Seabrook (Maryland) | 587.81 mi (946.00 km) |
| East Chicago to Seabrook (Texas) | 935.24 mi (1,505.12 km) |
| East Chicago to Seaford (New York) | 728.67 mi (1,172.67 km) |
| East Chicago to Seagoville (Texas) | 797.01 mi (1,282.66 km) |
| East Chicago to Seal Beach (California) | 1,749.62 mi (2,815.74 km) |
| East Chicago to Searcy (Arkansas) | 499.34 mi (803.61 km) |
| East Chicago to Seaside (California) | 1,861.42 mi (2,995.66 km) |
| East Chicago to SeaTac (Washington) | 1,746.26 mi (2,810.33 km) |
| East Chicago to Seattle (Washington) | 1,747.57 mi (2,812.44 km) |
| East Chicago to Sebastian (Florida) | 1,035.65 mi (1,666.72 km) |
| East Chicago to Sebring (Florida) | 1,036.18 mi (1,667.56 km) |
| East Chicago to Secaucus (New Jersey) | 697.74 mi (1,122.91 km) |
