| Duluth to Superior (Colorado) | 805.32 mi (1,296.04 km) |
| Duluth to Superior (Wisconsin) | 6.24 mi (10.05 km) |
| Duluth to Surprise (Arizona) | 1,394.91 mi (2,244.89 km) |
| Duluth to Susanville (California) | 1,481.53 mi (2,384.29 km) |
| Duluth to Sussex (Wisconsin) | 316.08 mi (508.68 km) |
| Duluth to Suwanee (Georgia) | 975.07 mi (1,569.23 km) |
| Duluth to Swansea (Illinois) | 578.66 mi (931.26 km) |
| Duluth to Sweetwater (Florida) | 1,587.71 mi (2,555.17 km) |
| Duluth to Sweetwater (Texas) | 1,080.54 mi (1,738.96 km) |
| Duluth to Sycamore (Illinois) | 371.67 mi (598.15 km) |
| Duluth to Sylacauga (Alabama) | 988.99 mi (1,591.62 km) |
| Duluth to Sylvania (Ohio) | 544.08 mi (875.61 km) |
| Duluth to Syosset (New York) | 1,013.37 mi (1,630.87 km) |
| Duluth to Syracuse (New York) | 822.45 mi (1,323.60 km) |
| Duluth to Syracuse (Utah) | 1,063.12 mi (1,710.93 km) |
