| Duluth to Southern Pines (North Carolina) | 1,037.31 mi (1,669.39 km) |
| Duluth to Southfield (Michigan) | 527.56 mi (849.03 km) |
| Duluth to Southgate (Michigan) | 541.33 mi (871.19 km) |
| Duluth to Southlake (Texas) | 990.69 mi (1,594.36 km) |
| Duluth to Spanaway (Washington) | 1,419.91 mi (2,285.12 km) |
| Duluth to Spanish Fork (Utah) | 1,077.40 mi (1,733.91 km) |
| Duluth to Spanish Lake (Missouri) | 560.44 mi (901.94 km) |
| Duluth to Spanish Springs (Nevada) | 1,461.87 mi (2,352.66 km) |
| Duluth to Sparks (Nevada) | 1,466.82 mi (2,360.62 km) |
| Duluth to Spartanburg (South Carolina) | 974.44 mi (1,568.21 km) |
| Duluth to Spearfish (South Dakota) | 585.16 mi (941.72 km) |
| Duluth to Speedway (Indiana) | 565.75 mi (910.49 km) |
| Duluth to Spencer (Iowa) | 290.77 mi (467.95 km) |
| Duluth to Spokane (Washington) | 1,183.25 mi (1,904.26 km) |
| Duluth to Spokane Valley (Washington) | 1,174.11 mi (1,889.55 km) |
