| Drobeta-Turnu Severin to Southern Pines (North Carolina) | 5,080.64 mi (8,176.49 km) |
| Drobeta-Turnu Severin to Southfield (Michigan) | 4,884.74 mi (7,861.22 km) |
| Drobeta-Turnu Severin to Southgate (Michigan) | 4,895.64 mi (7,878.78 km) |
| Drobeta-Turnu Severin to Southlake (Texas) | 5,879.82 mi (9,462.66 km) |
| Drobeta-Turnu Severin to Spanaway (Washington) | 5,752.31 mi (9,257.45 km) |
| Drobeta-Turnu Severin to Spanish Fork (Utah) | 5,930.79 mi (9,544.69 km) |
| Drobeta-Turnu Severin to Spanish Lake (Missouri) | 5,321.38 mi (8,563.93 km) |
| Drobeta-Turnu Severin to Spanish Springs (Nevada) | 6,159.90 mi (9,913.41 km) |
| Drobeta-Turnu Severin to Sparks (Nevada) | 6,166.16 mi (9,923.48 km) |
| Drobeta-Turnu Severin to Spartanburg (South Carolina) | 5,195.09 mi (8,360.69 km) |
| Drobeta-Turnu Severin to Spearfish (South Dakota) | 5,459.03 mi (8,785.46 km) |
| Drobeta-Turnu Severin to Speedway (Indiana) | 5,125.54 mi (8,248.76 km) |
| Drobeta-Turnu Severin to Spencer (Iowa) | 5,265.90 mi (8,474.65 km) |
| Drobeta-Turnu Severin to Spokane (Washington) | 5,615.08 mi (9,036.60 km) |
| Drobeta-Turnu Severin to Spokane Valley (Washington) | 5,611.08 mi (9,030.16 km) |
