| Domodossola to Southern Pines (North Carolina) | 4,422.86 mi (7,117.90 km) |
| Domodossola to Southfield (Michigan) | 4,268.55 mi (6,869.56 km) |
| Domodossola to Southgate (Michigan) | 4,277.96 mi (6,884.71 km) |
| Domodossola to Southlake (Texas) | 5,270.36 mi (8,481.82 km) |
| Domodossola to Spanaway (Washington) | 5,339.69 mi (8,593.40 km) |
| Domodossola to Spanish Fork (Utah) | 5,422.03 mi (8,725.91 km) |
| Domodossola to Spanish Lake (Missouri) | 4,710.94 mi (7,581.53 km) |
| Domodossola to Spanish Springs (Nevada) | 5,695.53 mi (9,166.07 km) |
| Domodossola to Sparks (Nevada) | 5,701.70 mi (9,176.00 km) |
| Domodossola to Spartanburg (South Carolina) | 4,543.04 mi (7,311.31 km) |
| Domodossola to Spearfish (South Dakota) | 4,933.09 mi (7,939.05 km) |
| Domodossola to Speedway (Indiana) | 4,506.23 mi (7,252.08 km) |
| Domodossola to Spencer (Iowa) | 4,695.36 mi (7,556.45 km) |
| Domodossola to Spokane (Washington) | 5,176.19 mi (8,330.27 km) |
| Domodossola to Spokane Valley (Washington) | 5,171.05 mi (8,322.01 km) |
