| Difficult Run to Worthington (Ohio) | 313.47 mi (504.49 km) |
| Difficult Run to Wright (Florida) | 786.74 mi (1,266.14 km) |
| Difficult Run to Wyandanch (New York) | 246.92 mi (397.39 km) |
| Difficult Run to Wyandotte (Michigan) | 381.00 mi (613.15 km) |
| Difficult Run to Wylie (Texas) | 1,143.22 mi (1,839.83 km) |
| Difficult Run to Wyndham (Virginia) | 84.78 mi (136.43 km) |
| Difficult Run to Wyoming (Michigan) | 515.94 mi (830.32 km) |
| Difficult Run to Wyomissing (Pennsylvania) | 123.01 mi (197.97 km) |
| Difficult Run to Xenia (Ohio) | 356.64 mi (573.95 km) |
| Difficult Run to Yakima (Washington) | 2,225.90 mi (3,582.24 km) |
| Difficult Run to Yankton (South Dakota) | 1,079.70 mi (1,737.62 km) |
| Difficult Run to Yauco (Puerto Rico) | 1,573.41 mi (2,532.15 km) |
| Difficult Run to Yazoo City (Mississippi) | 840.62 mi (1,352.84 km) |
| Difficult Run to Yeadon (Pennsylvania) | 132.55 mi (213.32 km) |
| Difficult Run to Yelm (Washington) | 2,323.03 mi (3,738.55 km) |
