| Difficult Run to Vega Baja (Puerto Rico) | 1,558.78 mi (2,508.61 km) |
| Difficult Run to Venice (Florida) | 865.04 mi (1,392.15 km) |
| Difficult Run to Verde Village (Arizona) | 1,926.68 mi (3,100.70 km) |
| Difficult Run to Vermilion (Ohio) | 314.63 mi (506.35 km) |
| Difficult Run to Vermillion (South Dakota) | 1,055.22 mi (1,698.21 km) |
| Difficult Run to Vernon (Texas) | 1,258.91 mi (2,026.01 km) |
| Difficult Run to Vernon Hills (Illinois) | 602.23 mi (969.20 km) |
| Difficult Run to Vero Beach (Florida) | 797.18 mi (1,282.93 km) |
| Difficult Run to Vero Beach South (Florida) | 799.71 mi (1,287.01 km) |
| Difficult Run to Verona (Wisconsin) | 695.23 mi (1,118.87 km) |
| Difficult Run to Versailles (Kentucky) | 403.34 mi (649.11 km) |
| Difficult Run to Vestavia Hills (Alabama) | 644.73 mi (1,037.60 km) |
| Difficult Run to Vicksburg (Mississippi) | 884.81 mi (1,423.97 km) |
| Difficult Run to Victoria (Minnesota) | 932.43 mi (1,500.61 km) |
| Difficult Run to Victoria (Texas) | 1,319.90 mi (2,124.17 km) |
