| Difficult Run to The Villages (Florida) | 740.02 mi (1,190.95 km) |
| Difficult Run to The Woodlands (Texas) | 1,193.65 mi (1,920.99 km) |
| Difficult Run to Thibodaux (Louisiana) | 991.09 mi (1,595.01 km) |
| Difficult Run to Thomasville (Georgia) | 671.55 mi (1,080.75 km) |
| Difficult Run to Thomasville (North Carolina) | 257.00 mi (413.61 km) |
| Difficult Run to Thonotosassa (Florida) | 801.96 mi (1,290.63 km) |
| Difficult Run to Thornton (Colorado) | 1,469.00 mi (2,364.12 km) |
| Difficult Run to Thousand Oaks (California) | 2,308.00 mi (3,714.37 km) |
| Difficult Run to Three Lakes (Florida) | 933.21 mi (1,501.86 km) |
| Difficult Run to Tiffin (Ohio) | 344.46 mi (554.35 km) |
| Difficult Run to Tifton (Georgia) | 620.69 mi (998.91 km) |
| Difficult Run to Tigard (Oregon) | 2,338.17 mi (3,762.92 km) |
| Difficult Run to Tillmans Corner (Alabama) | 842.03 mi (1,355.11 km) |
| Difficult Run to Timberlake (Virginia) | 150.57 mi (242.31 km) |
| Difficult Run to Timberlane (Louisiana) | 953.08 mi (1,533.84 km) |
