| Difficult Run to Tacoma (Washington) | 2,313.91 mi (3,723.88 km) |
| Difficult Run to Tahlequah (Oklahoma) | 987.73 mi (1,589.60 km) |
| Difficult Run to Takoma Park (Maryland) | 19.30 mi (31.06 km) |
| Difficult Run to Talladega (Alabama) | 616.77 mi (992.60 km) |
| Difficult Run to Tallahassee (Florida) | 702.71 mi (1,130.90 km) |
| Difficult Run to Tallmadge (Ohio) | 263.82 mi (424.57 km) |
| Difficult Run to Tamalpais-Homestead Valley (California) | 2,422.92 mi (3,899.31 km) |
| Difficult Run to Tamarac (Florida) | 893.25 mi (1,437.54 km) |
| Difficult Run to Tamiami (Florida) | 925.47 mi (1,489.41 km) |
| Difficult Run to Tampa (Florida) | 808.50 mi (1,301.15 km) |
| Difficult Run to Tanaina (Alaska) | 3,331.07 mi (5,360.83 km) |
| Difficult Run to Tanque Verde (Arizona) | 1,920.18 mi (3,090.24 km) |
| Difficult Run to Tarboro (North Carolina) | 207.39 mi (333.76 km) |
| Difficult Run to Tarpon Springs (Florida) | 805.31 mi (1,296.02 km) |
| Difficult Run to Tarrytown (New York) | 237.19 mi (381.73 km) |
