| Difficult Run to Sugar Hill (Georgia) | 498.24 mi (801.85 km) |
| Difficult Run to Sugar Land (Texas) | 1,223.09 mi (1,968.38 km) |
| Difficult Run to Sugarland Run (Virginia) | 9.07 mi (14.60 km) |
| Difficult Run to Sugarmill Woods (Florida) | 762.17 mi (1,226.59 km) |
| Difficult Run to Suisun City (California) | 2,388.32 mi (3,843.63 km) |
| Difficult Run to Suitland (Maryland) | 23.12 mi (37.22 km) |
| Difficult Run to Sulphur (Louisiana) | 1,087.76 mi (1,750.59 km) |
| Difficult Run to Sulphur Springs (Texas) | 1,093.08 mi (1,759.15 km) |
| Difficult Run to Summerfield (Maryland) | 25.77 mi (41.48 km) |
| Difficult Run to Summerfield (North Carolina) | 233.35 mi (375.54 km) |
| Difficult Run to Summerlin South (Nevada) | 2,075.63 mi (3,340.41 km) |
| Difficult Run to Summerville (South Carolina) | 437.29 mi (703.75 km) |
| Difficult Run to Summit (Illinois) | 585.71 mi (942.61 km) |
| Difficult Run to Summit (New Jersey) | 201.88 mi (324.89 km) |
| Difficult Run to Sumner (Washington) | 2,303.70 mi (3,707.45 km) |
