| Difficult Run to Storm Lake (Iowa) | 966.98 mi (1,556.21 km) |
| Difficult Run to Storrs (Connecticut) | 335.04 mi (539.19 km) |
| Difficult Run to Stoughton (Wisconsin) | 678.68 mi (1,092.23 km) |
| Difficult Run to Stow (Ohio) | 267.26 mi (430.11 km) |
| Difficult Run to Streamwood (Illinois) | 608.25 mi (978.88 km) |
| Difficult Run to Streator (Illinois) | 626.23 mi (1,007.82 km) |
| Difficult Run to Streetsboro (Ohio) | 266.02 mi (428.11 km) |
| Difficult Run to Strongsville (Ohio) | 289.61 mi (466.08 km) |
| Difficult Run to Stuart (Florida) | 825.87 mi (1,329.11 km) |
| Difficult Run to Stuarts Draft (Virginia) | 109.83 mi (176.76 km) |
| Difficult Run to Sturgis (Michigan) | 469.53 mi (755.64 km) |
| Difficult Run to Suamico (Wisconsin) | 678.92 mi (1,092.62 km) |
| Difficult Run to Sudley (Virginia) | 11.23 mi (18.07 km) |
| Difficult Run to Suffern (New York) | 228.29 mi (367.40 km) |
| Difficult Run to Suffolk (Virginia) | 157.25 mi (253.08 km) |
