| Difficult Run to Stephenville (Texas) | 1,257.33 mi (2,023.48 km) |
| Difficult Run to Sterling (Colorado) | 1,372.91 mi (2,209.48 km) |
| Difficult Run to Sterling (Illinois) | 679.64 mi (1,093.77 km) |
| Difficult Run to Sterling (Virginia) | 7.80 mi (12.56 km) |
| Difficult Run to Sterling Heights (Michigan) | 391.17 mi (629.53 km) |
| Difficult Run to Steubenville (Ohio) | 202.84 mi (326.44 km) |
| Difficult Run to Stevens Point (Wisconsin) | 738.48 mi (1,188.47 km) |
| Difficult Run to Stevenson Ranch (California) | 2,287.88 mi (3,681.99 km) |
| Difficult Run to Stillwater (Minnesota) | 899.78 mi (1,448.06 km) |
| Difficult Run to Stillwater (Oklahoma) | 1,095.67 mi (1,763.30 km) |
| Difficult Run to Stockbridge (Georgia) | 533.70 mi (858.91 km) |
| Difficult Run to Stockton (California) | 2,356.73 mi (3,792.79 km) |
| Difficult Run to Stone Ridge (Virginia) | 11.38 mi (18.31 km) |
| Difficult Run to Stonecrest (Georgia) | 522.13 mi (840.29 km) |
| Difficult Run to Stony Brook (New York) | 263.00 mi (423.26 km) |
