| Difficult Run to St. Simons (Georgia) | 580.35 mi (933.99 km) |
| Difficult Run to Stafford (Texas) | 1,218.31 mi (1,960.69 km) |
| Difficult Run to Stallings (North Carolina) | 319.45 mi (514.10 km) |
| Difficult Run to Stamford (Connecticut) | 251.67 mi (405.03 km) |
| Difficult Run to Stanford (California) | 2,412.26 mi (3,882.16 km) |
| Difficult Run to Stanton (California) | 2,270.24 mi (3,653.61 km) |
| Difficult Run to Star (Idaho) | 2,039.35 mi (3,282.02 km) |
| Difficult Run to Starkville (Mississippi) | 741.70 mi (1,193.64 km) |
| Difficult Run to State College (Pennsylvania) | 133.31 mi (214.54 km) |
| Difficult Run to Staten Island (New York) | 205.79 mi (331.19 km) |
| Difficult Run to Statesboro (Georgia) | 510.95 mi (822.30 km) |
| Difficult Run to Statesville (North Carolina) | 289.55 mi (465.99 km) |
| Difficult Run to Staunton (Virginia) | 105.89 mi (170.41 km) |
| Difficult Run to Steamboat Springs (Colorado) | 1,563.75 mi (2,516.61 km) |
| Difficult Run to Steiner Ranch (Texas) | 1,304.48 mi (2,099.35 km) |
