| Difficult Run to St. George (Utah) | 1,963.87 mi (3,160.54 km) |
| Difficult Run to St. Helens (Oregon) | 2,337.08 mi (3,761.17 km) |
| Difficult Run to St. James (New York) | 260.86 mi (419.81 km) |
| Difficult Run to St. John (Indiana) | 562.12 mi (904.65 km) |
| Difficult Run to St. Joseph (Missouri) | 934.27 mi (1,503.56 km) |
| Difficult Run to St. Louis (Missouri) | 694.49 mi (1,117.67 km) |
| Difficult Run to St. Louis Park (Minnesota) | 921.12 mi (1,482.40 km) |
| Difficult Run to St. Marys (Georgia) | 611.45 mi (984.04 km) |
| Difficult Run to St. Marys (Pennsylvania) | 187.37 mi (301.55 km) |
| Difficult Run to St. Matthews (Kentucky) | 449.96 mi (724.15 km) |
| Difficult Run to St. Michael (Minnesota) | 942.38 mi (1,516.61 km) |
| Difficult Run to St. Paul (Minnesota) | 909.23 mi (1,463.26 km) |
| Difficult Run to St. Peter (Minnesota) | 934.58 mi (1,504.06 km) |
| Difficult Run to St. Peters (Missouri) | 712.96 mi (1,147.39 km) |
| Difficult Run to St. Petersburg (Florida) | 826.20 mi (1,329.64 km) |
