| Difficult Run to Spout Springs (North Carolina) | 267.40 mi (430.34 km) |
| Difficult Run to Spring (Texas) | 1,191.80 mi (1,918.02 km) |
| Difficult Run to Spring Creek (Nevada) | 2,017.72 mi (3,247.21 km) |
| Difficult Run to Spring Hill (Florida) | 778.91 mi (1,253.53 km) |
| Difficult Run to Spring Hill (Tennessee) | 568.64 mi (915.14 km) |
| Difficult Run to Spring Lake (North Carolina) | 272.45 mi (438.47 km) |
| Difficult Run to Spring Valley (California) | 2,242.83 mi (3,609.48 km) |
| Difficult Run to Spring Valley (Nevada) | 2,072.54 mi (3,335.44 km) |
| Difficult Run to Spring Valley (New York) | 232.05 mi (373.45 km) |
| Difficult Run to Springboro (Ohio) | 371.34 mi (597.61 km) |
| Difficult Run to Springdale (Arkansas) | 938.32 mi (1,510.08 km) |
| Difficult Run to Springdale (New Jersey) | 143.59 mi (231.09 km) |
| Difficult Run to Springdale (Ohio) | 383.11 mi (616.56 km) |
| Difficult Run to Springfield (Illinois) | 659.89 mi (1,061.98 km) |
| Difficult Run to Springfield (Massachusetts) | 336.19 mi (541.05 km) |
