| Difficult Run to Shoreview (Minnesota) | 914.22 mi (1,471.29 km) |
| Difficult Run to Shorewood (Illinois) | 600.74 mi (966.80 km) |
| Difficult Run to Shorewood (Wisconsin) | 620.53 mi (998.65 km) |
| Difficult Run to Short Hills (New Jersey) | 204.40 mi (328.95 km) |
| Difficult Run to Short Pump (Virginia) | 87.40 mi (140.66 km) |
| Difficult Run to Show Low (Arizona) | 1,831.70 mi (2,947.84 km) |
| Difficult Run to Shreveport (Louisiana) | 1,022.54 mi (1,645.63 km) |
| Difficult Run to Sicklerville (New Jersey) | 138.64 mi (223.13 km) |
| Difficult Run to Sidney (Ohio) | 375.41 mi (604.17 km) |
| Difficult Run to Sierra Madre (California) | 2,264.33 mi (3,644.09 km) |
| Difficult Run to Sierra Vista (Arizona) | 1,916.97 mi (3,085.06 km) |
| Difficult Run to Sierra Vista Southeast (Arizona) | 1,914.83 mi (3,081.62 km) |
| Difficult Run to Signal Hill (California) | 2,279.54 mi (3,668.57 km) |
| Difficult Run to Sikeston (Missouri) | 681.24 mi (1,096.35 km) |
| Difficult Run to Siloam Springs (Arkansas) | 958.43 mi (1,542.45 km) |
