| Difficult Run to Shelton (Connecticut) | 277.56 mi (446.69 km) |
| Difficult Run to Shelton (Washington) | 2,344.88 mi (3,773.71 km) |
| Difficult Run to Shenandoah (Louisiana) | 971.40 mi (1,563.32 km) |
| Difficult Run to Shepherdsville (Kentucky) | 456.35 mi (734.43 km) |
| Difficult Run to Sheridan (Wyoming) | 1,568.19 mi (2,523.75 km) |
| Difficult Run to Sherman (Texas) | 1,131.32 mi (1,820.69 km) |
| Difficult Run to Sherrelwood (Colorado) | 1,472.64 mi (2,369.99 km) |
| Difficult Run to Sherwood (Arkansas) | 866.25 mi (1,394.10 km) |
| Difficult Run to Sherwood (Oregon) | 2,341.40 mi (3,768.11 km) |
| Difficult Run to Shiloh (Illinois) | 677.38 mi (1,090.14 km) |
| Difficult Run to Shiloh (Ohio) | 373.08 mi (600.41 km) |
| Difficult Run to Shiloh (Pennsylvania) | 79.75 mi (128.34 km) |
| Difficult Run to Shirley (New York) | 270.82 mi (435.84 km) |
| Difficult Run to Shively (Kentucky) | 459.91 mi (740.15 km) |
| Difficult Run to Shoreline (Washington) | 2,307.54 mi (3,713.63 km) |
