| Difficult Run to Scottsboro (Alabama) | 563.96 mi (907.60 km) |
| Difficult Run to Scottsdale (Arizona) | 1,943.76 mi (3,128.18 km) |
| Difficult Run to Scranton (Pennsylvania) | 194.40 mi (312.86 km) |
| Difficult Run to Seabrook (Maryland) | 27.25 mi (43.85 km) |
| Difficult Run to Seabrook (Texas) | 1,194.45 mi (1,922.29 km) |
| Difficult Run to Seaford (New York) | 238.26 mi (383.44 km) |
| Difficult Run to Seagoville (Texas) | 1,156.67 mi (1,861.48 km) |
| Difficult Run to Seal Beach (California) | 2,275.56 mi (3,662.16 km) |
| Difficult Run to Searcy (Arkansas) | 831.44 mi (1,338.08 km) |
| Difficult Run to Seaside (California) | 2,410.23 mi (3,878.88 km) |
| Difficult Run to SeaTac (Washington) | 2,306.15 mi (3,711.40 km) |
| Difficult Run to Seattle (Washington) | 2,306.96 mi (3,712.70 km) |
| Difficult Run to Sebastian (Florida) | 789.14 mi (1,270.01 km) |
| Difficult Run to Sebring (Florida) | 824.03 mi (1,326.15 km) |
| Difficult Run to Secaucus (New Jersey) | 217.14 mi (349.46 km) |
