| Difficult Run to Savannah (Georgia) | 521.48 mi (839.23 km) |
| Difficult Run to Sayreville (New Jersey) | 193.69 mi (311.71 km) |
| Difficult Run to Sayville (New York) | 259.66 mi (417.88 km) |
| Difficult Run to Scaggsville (Maryland) | 29.87 mi (48.07 km) |
| Difficult Run to Scarsdale (New York) | 237.83 mi (382.75 km) |
| Difficult Run to Schaumburg (Illinois) | 603.84 mi (971.79 km) |
| Difficult Run to Schenectady (New York) | 323.33 mi (520.34 km) |
| Difficult Run to Schererville (Indiana) | 561.62 mi (903.84 km) |
| Difficult Run to Schertz (Texas) | 1,352.68 mi (2,176.93 km) |
| Difficult Run to Schiller Park (Illinois) | 591.84 mi (952.47 km) |
| Difficult Run to Schofield Barracks (Hawaii) | 4,815.83 mi (7,750.34 km) |
| Difficult Run to Scotchtown (New York) | 237.45 mi (382.13 km) |
| Difficult Run to Scottdale (Georgia) | 521.83 mi (839.81 km) |
| Difficult Run to Scotts Valley (California) | 2,411.45 mi (3,880.86 km) |
| Difficult Run to Scottsbluff (Nebraska) | 1,394.39 mi (2,244.06 km) |
