| Difficult Run to Santa Rosa (California) | 2,421.14 mi (3,896.45 km) |
| Difficult Run to Santaquin (Utah) | 1,828.21 mi (2,942.22 km) |
| Difficult Run to Santee (California) | 2,240.04 mi (3,605.00 km) |
| Difficult Run to Sapulpa (Oklahoma) | 1,045.84 mi (1,683.12 km) |
| Difficult Run to Saraland (Alabama) | 824.21 mi (1,326.44 km) |
| Difficult Run to Sarasota (Florida) | 853.21 mi (1,373.11 km) |
| Difficult Run to Sarasota Springs (Florida) | 853.79 mi (1,374.04 km) |
| Difficult Run to Saratoga (California) | 2,407.94 mi (3,875.21 km) |
| Difficult Run to Saratoga Springs (New York) | 342.72 mi (551.55 km) |
| Difficult Run to Saratoga Springs (Utah) | 1,830.70 mi (2,946.22 km) |
| Difficult Run to Sartell (Minnesota) | 976.98 mi (1,572.29 km) |
| Difficult Run to Satellite Beach (Florida) | 764.10 mi (1,229.70 km) |
| Difficult Run to Sauk Rapids (Minnesota) | 973.45 mi (1,566.61 km) |
| Difficult Run to Sault Ste. Marie (Michigan) | 633.13 mi (1,018.92 km) |
| Difficult Run to Savage (Minnesota) | 916.24 mi (1,474.54 km) |
