| Difficult Run to Sanford (Maine) | 463.56 mi (746.03 km) |
| Difficult Run to Sanford (North Carolina) | 256.48 mi (412.76 km) |
| Difficult Run to Sanger (California) | 2,288.90 mi (3,683.63 km) |
| Difficult Run to Santa Ana (California) | 2,265.83 mi (3,646.50 km) |
| Difficult Run to Santa Barbara (California) | 2,347.52 mi (3,777.98 km) |
| Difficult Run to Santa Clara (California) | 2,402.97 mi (3,867.20 km) |
| Difficult Run to Santa Clara (Oregon) | 2,365.31 mi (3,806.59 km) |
| Difficult Run to Santa Clarita (California) | 2,282.29 mi (3,673.00 km) |
| Difficult Run to Santa Cruz (California) | 2,414.21 mi (3,885.30 km) |
| Difficult Run to Santa Fe (New Mexico) | 1,583.43 mi (2,548.28 km) |
| Difficult Run to Santa Fe (Texas) | 1,205.95 mi (1,940.79 km) |
| Difficult Run to Santa Fe Springs (California) | 2,270.69 mi (3,654.33 km) |
| Difficult Run to Santa Maria (California) | 2,374.27 mi (3,821.02 km) |
| Difficult Run to Santa Monica (California) | 2,290.92 mi (3,686.89 km) |
| Difficult Run to Santa Paula (California) | 2,314.26 mi (3,724.45 km) |
