| Difficult Run to San Diego (California) | 2,248.04 mi (3,617.87 km) |
| Difficult Run to San Diego Country Estates (California) | 2,225.42 mi (3,581.47 km) |
| Difficult Run to San Dimas (California) | 2,252.85 mi (3,625.61 km) |
| Difficult Run to San Fernando (California) | 2,282.13 mi (3,672.74 km) |
| Difficult Run to San Francisco (California) | 2,420.39 mi (3,895.25 km) |
| Difficult Run to San Gabriel (California) | 2,268.72 mi (3,651.15 km) |
| Difficult Run to San Germán (Puerto Rico) | 1,565.89 mi (2,520.06 km) |
| Difficult Run to San Jacinto (California) | 2,216.56 mi (3,567.21 km) |
| Difficult Run to San Jose (California) | 2,397.90 mi (3,859.05 km) |
| Difficult Run to San Juan (Puerto Rico) | 1,570.11 mi (2,526.84 km) |
| Difficult Run to San Juan (Texas) | 1,490.47 mi (2,398.69 km) |
| Difficult Run to San Juan Capistrano (California) | 2,259.49 mi (3,636.30 km) |
| Difficult Run to San Leandro (California) | 2,406.37 mi (3,872.68 km) |
| Difficult Run to San Lorenzo (California) | 2,405.63 mi (3,871.48 km) |
| Difficult Run to San Luis (Arizona) | 2,127.27 mi (3,423.51 km) |
