| Difficult Run to Saddlebrooke (Arizona) | 1,919.38 mi (3,088.94 km) |
| Difficult Run to Safety Harbor (Florida) | 812.97 mi (1,308.35 km) |
| Difficult Run to Saginaw (Michigan) | 463.87 mi (746.53 km) |
| Difficult Run to Saginaw (Texas) | 1,192.61 mi (1,919.32 km) |
| Difficult Run to Sahuarita (Arizona) | 1,941.36 mi (3,124.32 km) |
| Difficult Run to Saks (Alabama) | 593.60 mi (955.31 km) |
| Difficult Run to Salem (Massachusetts) | 419.57 mi (675.23 km) |
| Difficult Run to Salem (Ohio) | 231.52 mi (372.59 km) |
| Difficult Run to Salem (Oregon) | 2,353.27 mi (3,787.23 km) |
| Difficult Run to Salem (Virginia) | 184.77 mi (297.35 km) |
| Difficult Run to Salem Lakes (Wisconsin) | 617.43 mi (993.65 km) |
| Difficult Run to Salida (California) | 2,349.84 mi (3,781.70 km) |
| Difficult Run to Salina (Kansas) | 1,088.21 mi (1,751.30 km) |
| Difficult Run to Salinas (California) | 2,398.91 mi (3,860.67 km) |
| Difficult Run to Salisbury (Maryland) | 101.73 mi (163.72 km) |
