| Difficult Run to Punta Gorda (Florida) | 873.01 mi (1,404.98 km) |
| Difficult Run to Puyallup (Washington) | 2,306.46 mi (3,711.88 km) |
| Difficult Run to Queen Creek (Arizona) | 1,941.43 mi (3,124.44 km) |
| Difficult Run to Queens (New York) | 227.53 mi (366.17 km) |
| Difficult Run to Quincy (Illinois) | 751.63 mi (1,209.64 km) |
| Difficult Run to Quincy (Massachusetts) | 404.59 mi (651.12 km) |
| Difficult Run to Raceland (Louisiana) | 986.45 mi (1,587.55 km) |
| Difficult Run to Racine (Wisconsin) | 607.21 mi (977.21 km) |
| Difficult Run to Radcliff (Kentucky) | 471.12 mi (758.20 km) |
| Difficult Run to Radford (Virginia) | 213.68 mi (343.88 km) |
| Difficult Run to Rahway (New Jersey) | 201.04 mi (323.54 km) |
| Difficult Run to Raleigh (North Carolina) | 223.67 mi (359.97 km) |
| Difficult Run to Ramona (California) | 2,229.24 mi (3,587.61 km) |
| Difficult Run to Ramsey (Minnesota) | 933.01 mi (1,501.53 km) |
| Difficult Run to Ramsey (New Jersey) | 225.72 mi (363.26 km) |
