| Difficult Run to Pottsville (Pennsylvania) | 136.91 mi (220.33 km) |
| Difficult Run to Poughkeepsie (New York) | 264.24 mi (425.25 km) |
| Difficult Run to Poulsbo (Washington) | 2,321.41 mi (3,735.95 km) |
| Difficult Run to Poway (California) | 2,238.50 mi (3,602.52 km) |
| Difficult Run to Powder Springs (Georgia) | 535.96 mi (862.54 km) |
| Difficult Run to Powell (Ohio) | 317.87 mi (511.56 km) |
| Difficult Run to Powell (Tennessee) | 416.37 mi (670.08 km) |
| Difficult Run to Prairie Ridge (Washington) | 2,299.54 mi (3,700.76 km) |
| Difficult Run to Prairie Village (Kansas) | 927.69 mi (1,492.98 km) |
| Difficult Run to Prairieville (Louisiana) | 973.32 mi (1,566.41 km) |
| Difficult Run to Prattville (Alabama) | 677.23 mi (1,089.89 km) |
| Difficult Run to Preakness (New Jersey) | 217.20 mi (349.54 km) |
| Difficult Run to Prescott (Arizona) | 1,953.90 mi (3,144.49 km) |
| Difficult Run to Prescott Valley (Arizona) | 1,946.68 mi (3,132.88 km) |
| Difficult Run to Prichard (Alabama) | 829.11 mi (1,334.33 km) |
