| Difficult Run to Oxford (Alabama) | 599.37 mi (964.59 km) |
| Difficult Run to Oxford (Mississippi) | 744.09 mi (1,197.49 km) |
| Difficult Run to Oxford (Ohio) | 398.15 mi (640.76 km) |
| Difficult Run to Oxnard (California) | 2,324.26 mi (3,740.54 km) |
| Difficult Run to Oxon Hill (Maryland) | 21.61 mi (34.78 km) |
| Difficult Run to Ozark (Alabama) | 695.60 mi (1,119.46 km) |
| Difficult Run to Ozark (Missouri) | 872.76 mi (1,404.58 km) |
| Difficult Run to Pace (Florida) | 797.89 mi (1,284.08 km) |
| Difficult Run to Pacific Grove (California) | 2,415.90 mi (3,888.02 km) |
| Difficult Run to Pacifica (California) | 2,424.94 mi (3,902.57 km) |
| Difficult Run to Paducah (Kentucky) | 627.61 mi (1,010.04 km) |
| Difficult Run to Pahrump (Nevada) | 2,109.13 mi (3,394.32 km) |
| Difficult Run to Painesville (Ohio) | 283.47 mi (456.20 km) |
| Difficult Run to Palatine (Illinois) | 603.68 mi (971.53 km) |
| Difficult Run to Palatka (Florida) | 685.04 mi (1,102.46 km) |
