| Difficult Run to Odessa (Texas) | 1,483.57 mi (2,387.58 km) |
| Difficult Run to Ogden (Utah) | 1,825.63 mi (2,938.07 km) |
| Difficult Run to Oildale (California) | 2,287.68 mi (3,681.67 km) |
| Difficult Run to Ojus (Florida) | 909.22 mi (1,463.25 km) |
| Difficult Run to Okemos (Michigan) | 453.25 mi (729.43 km) |
| Difficult Run to Oklahoma City (Oklahoma) | 1,132.65 mi (1,822.83 km) |
| Difficult Run to Okmulgee (Oklahoma) | 1,048.99 mi (1,688.19 km) |
| Difficult Run to Olathe (Kansas) | 938.20 mi (1,509.89 km) |
| Difficult Run to Old Jamestown (Missouri) | 695.39 mi (1,119.12 km) |
| Difficult Run to Oldsmar (Florida) | 809.64 mi (1,303.00 km) |
| Difficult Run to Olean (New York) | 227.01 mi (365.33 km) |
| Difficult Run to Olive Branch (Mississippi) | 741.31 mi (1,193.03 km) |
| Difficult Run to Olivehurst (California) | 2,350.10 mi (3,782.12 km) |
| Difficult Run to Olney (Maryland) | 22.48 mi (36.17 km) |
| Difficult Run to Olympia (Washington) | 2,335.35 mi (3,758.39 km) |
