| Difficult Run to Nocatee (Florida) | 650.91 mi (1,047.54 km) |
| Difficult Run to Nogales (Arizona) | 1,955.86 mi (3,147.66 km) |
| Difficult Run to Nolensville (Tennessee) | 550.25 mi (885.54 km) |
| Difficult Run to Norco (California) | 2,243.38 mi (3,610.37 km) |
| Difficult Run to Norcross (Georgia) | 512.61 mi (824.96 km) |
| Difficult Run to Norfolk (Nebraska) | 1,074.51 mi (1,729.26 km) |
| Difficult Run to Norfolk (Virginia) | 150.83 mi (242.74 km) |
| Difficult Run to Normal (Illinois) | 628.30 mi (1,011.16 km) |
| Difficult Run to Norman (Oklahoma) | 1,128.88 mi (1,816.76 km) |
| Difficult Run to Norridge (Illinois) | 589.68 mi (949.00 km) |
| Difficult Run to Norristown (Pennsylvania) | 136.25 mi (219.27 km) |
| Difficult Run to North Adams (Massachusetts) | 342.37 mi (550.99 km) |
| Difficult Run to North Amityville (New York) | 243.03 mi (391.13 km) |
| Difficult Run to North Arlington (New Jersey) | 214.80 mi (345.69 km) |
| Difficult Run to North Auburn (California) | 2,327.88 mi (3,746.37 km) |
