| Difficult Run to Newport East (Rhode Island) | 367.09 mi (590.78 km) |
| Difficult Run to Newport News (Virginia) | 132.07 mi (212.54 km) |
| Difficult Run to Newton (Iowa) | 847.91 mi (1,364.57 km) |
| Difficult Run to Newton (Kansas) | 1,081.29 mi (1,740.16 km) |
| Difficult Run to Newton (Massachusetts) | 399.60 mi (643.09 km) |
| Difficult Run to Newton (North Carolina) | 309.32 mi (497.80 km) |
| Difficult Run to Niagara Falls (New York) | 302.29 mi (486.50 km) |
| Difficult Run to Niceville (Florida) | 775.91 mi (1,248.71 km) |
| Difficult Run to Nicholasville (Kentucky) | 397.03 mi (638.96 km) |
| Difficult Run to Niles (Illinois) | 590.39 mi (950.13 km) |
| Difficult Run to Niles (Michigan) | 510.14 mi (821.00 km) |
| Difficult Run to Niles (Ohio) | 239.57 mi (385.55 km) |
| Difficult Run to Nipomo (California) | 2,374.95 mi (3,822.11 km) |
| Difficult Run to Nixa (Missouri) | 876.92 mi (1,411.27 km) |
| Difficult Run to Noblesville (Indiana) | 468.16 mi (753.42 km) |
