| Difficult Run to Myrtle Grove (North Carolina) | 331.51 mi (533.51 km) |
| Difficult Run to Nacogdoches (Texas) | 1,096.01 mi (1,763.86 km) |
| Difficult Run to Nampa (Idaho) | 2,043.59 mi (3,288.84 km) |
| Difficult Run to Nanakuli (Hawaii) | 4,824.34 mi (7,764.02 km) |
| Difficult Run to Nanticoke (Pennsylvania) | 174.07 mi (280.14 km) |
| Difficult Run to Nanuet (New York) | 232.51 mi (374.19 km) |
| Difficult Run to Napa (California) | 2,402.67 mi (3,866.72 km) |
| Difficult Run to Naperville (Illinois) | 602.36 mi (969.40 km) |
| Difficult Run to Naples (Florida) | 917.97 mi (1,477.33 km) |
| Difficult Run to Naranja (Florida) | 941.97 mi (1,515.95 km) |
| Difficult Run to Nashua (New Hampshire) | 405.29 mi (652.26 km) |
| Difficult Run to Nashville (Tennessee) | 550.05 mi (885.22 km) |
| Difficult Run to Natchez (Mississippi) | 939.79 mi (1,512.45 km) |
| Difficult Run to Natchitoches (Louisiana) | 1,014.73 mi (1,633.05 km) |
| Difficult Run to National City (California) | 2,251.11 mi (3,622.82 km) |
