| Difficult Run to Mitchell (South Dakota) | 1,120.71 mi (1,803.61 km) |
| Difficult Run to Mitchellville (Maryland) | 28.72 mi (46.23 km) |
| Difficult Run to Moberly (Missouri) | 808.24 mi (1,300.74 km) |
| Difficult Run to Mobile (Alabama) | 833.25 mi (1,340.99 km) |
| Difficult Run to Modesto (California) | 2,346.90 mi (3,776.97 km) |
| Difficult Run to Mokena (Illinois) | 584.14 mi (940.09 km) |
| Difficult Run to Moline (Illinois) | 715.53 mi (1,151.54 km) |
| Difficult Run to Moncks Corner (South Carolina) | 422.80 mi (680.43 km) |
| Difficult Run to Monfort Heights (Ohio) | 390.00 mi (627.64 km) |
| Difficult Run to Monmouth (Oregon) | 2,363.75 mi (3,804.09 km) |
| Difficult Run to Monroe (Georgia) | 499.65 mi (804.11 km) |
| Difficult Run to Monroe (Louisiana) | 935.07 mi (1,504.86 km) |
| Difficult Run to Monroe (Michigan) | 379.68 mi (611.03 km) |
| Difficult Run to Monroe (North Carolina) | 322.28 mi (518.65 km) |
| Difficult Run to Monroe (Ohio) | 377.77 mi (607.97 km) |
