| Difficult Run to Mineral Wells (Texas) | 1,231.25 mi (1,981.51 km) |
| Difficult Run to Minneapolis (Minnesota) | 917.08 mi (1,475.89 km) |
| Difficult Run to Minnehaha (Washington) | 2,328.82 mi (3,747.87 km) |
| Difficult Run to Minneola (Florida) | 754.33 mi (1,213.97 km) |
| Difficult Run to Minnetonka (Minnesota) | 925.03 mi (1,488.70 km) |
| Difficult Run to Minooka (Illinois) | 602.90 mi (970.28 km) |
| Difficult Run to Minot (North Dakota) | 1,352.59 mi (2,176.79 km) |
| Difficult Run to Mint Hill (North Carolina) | 315.25 mi (507.35 km) |
| Difficult Run to Miramar (Florida) | 909.66 mi (1,463.96 km) |
| Difficult Run to Mishawaka (Indiana) | 502.45 mi (808.61 km) |
| Difficult Run to Mission (Texas) | 1,497.96 mi (2,410.73 km) |
| Difficult Run to Mission Bend (Texas) | 1,220.39 mi (1,964.02 km) |
| Difficult Run to Mission Viejo (California) | 2,256.81 mi (3,631.98 km) |
| Difficult Run to Missoula (Montana) | 1,917.05 mi (3,085.19 km) |
| Difficult Run to Missouri City (Texas) | 1,219.56 mi (1,962.70 km) |
