| Difficult Run to Mendota Heights (Minnesota) | 909.18 mi (1,463.18 km) |
| Difficult Run to Menifee (California) | 2,229.55 mi (3,588.12 km) |
| Difficult Run to Menlo Park (California) | 2,411.41 mi (3,880.78 km) |
| Difficult Run to Menomonee Falls (Wisconsin) | 633.03 mi (1,018.76 km) |
| Difficult Run to Menomonie (Wisconsin) | 853.76 mi (1,374.00 km) |
| Difficult Run to Mentor (Ohio) | 285.06 mi (458.75 km) |
| Difficult Run to Mequon (Wisconsin) | 629.13 mi (1,012.48 km) |
| Difficult Run to Merced (California) | 2,325.60 mi (3,742.70 km) |
| Difficult Run to Mercedes (Texas) | 1,481.04 mi (2,383.51 km) |
| Difficult Run to Mercer Island (Washington) | 2,302.77 mi (3,705.96 km) |
| Difficult Run to Mercerville (New Jersey) | 168.82 mi (271.68 km) |
| Difficult Run to Meriden (Connecticut) | 301.32 mi (484.93 km) |
| Difficult Run to Meridian (Idaho) | 2,035.16 mi (3,275.27 km) |
| Difficult Run to Meridian (Mississippi) | 778.97 mi (1,253.64 km) |
| Difficult Run to Merriam (Kansas) | 930.56 mi (1,497.59 km) |
