| Difficult Run to Medford (New York) | 266.61 mi (429.06 km) |
| Difficult Run to Medford (Oregon) | 2,369.90 mi (3,813.98 km) |
| Difficult Run to Medina (Ohio) | 284.71 mi (458.19 km) |
| Difficult Run to Medulla (Florida) | 801.81 mi (1,290.38 km) |
| Difficult Run to Mehlville (Missouri) | 699.20 mi (1,125.25 km) |
| Difficult Run to Melbourne (Florida) | 769.64 mi (1,238.61 km) |
| Difficult Run to Melissa (Texas) | 1,137.76 mi (1,831.04 km) |
| Difficult Run to Melrose (Massachusetts) | 410.74 mi (661.01 km) |
| Difficult Run to Melrose Park (Illinois) | 590.42 mi (950.19 km) |
| Difficult Run to Melville (New York) | 246.01 mi (395.91 km) |
| Difficult Run to Melvindale (Michigan) | 384.67 mi (619.07 km) |
| Difficult Run to Memphis (Florida) | 840.22 mi (1,352.21 km) |
| Difficult Run to Memphis (Tennessee) | 743.17 mi (1,196.01 km) |
| Difficult Run to Menasha (Wisconsin) | 679.40 mi (1,093.38 km) |
| Difficult Run to Mendota (California) | 2,331.20 mi (3,751.70 km) |
