| Difficult Run to Manor (Texas) | 1,286.07 mi (2,069.73 km) |
| Difficult Run to Manorville (New York) | 276.72 mi (445.34 km) |
| Difficult Run to Mansfield (Ohio) | 303.47 mi (488.38 km) |
| Difficult Run to Mansfield (Texas) | 1,189.12 mi (1,913.70 km) |
| Difficult Run to Manteca (California) | 2,355.72 mi (3,791.17 km) |
| Difficult Run to Manville (New Jersey) | 185.26 mi (298.15 km) |
| Difficult Run to Maple Grove (Minnesota) | 929.63 mi (1,496.09 km) |
| Difficult Run to Maple Heights (Ohio) | 282.03 mi (453.89 km) |
| Difficult Run to Maple Valley (Washington) | 2,294.10 mi (3,692.00 km) |
| Difficult Run to Mapleton (Utah) | 1,815.17 mi (2,921.23 km) |
| Difficult Run to Maplewood (Minnesota) | 906.58 mi (1,459.00 km) |
| Difficult Run to Marana (Arizona) | 1,937.79 mi (3,118.57 km) |
| Difficult Run to Marco Island (Florida) | 930.97 mi (1,498.26 km) |
| Difficult Run to Margate (Florida) | 890.00 mi (1,432.32 km) |
| Difficult Run to Maricopa (Arizona) | 1,967.29 mi (3,166.04 km) |
