| Difficult Run to Lowell (Indiana) | 557.00 mi (896.40 km) |
| Difficult Run to Lowell (Massachusetts) | 407.35 mi (655.56 km) |
| Difficult Run to Lower Burrell (Pennsylvania) | 171.13 mi (275.41 km) |
| Difficult Run to Lowes Island (Virginia) | 10.06 mi (16.19 km) |
| Difficult Run to Lubbock (Texas) | 1,411.70 mi (2,271.91 km) |
| Difficult Run to Lufkin (Texas) | 1,110.57 mi (1,787.28 km) |
| Difficult Run to Luling (Louisiana) | 965.90 mi (1,554.47 km) |
| Difficult Run to Lumberton (North Carolina) | 309.20 mi (497.61 km) |
| Difficult Run to Lumberton (Texas) | 1,127.09 mi (1,813.88 km) |
| Difficult Run to Lutz (Florida) | 799.12 mi (1,286.06 km) |
| Difficult Run to Lynbrook (New York) | 229.67 mi (369.61 km) |
| Difficult Run to Lynchburg (Virginia) | 144.20 mi (232.07 km) |
| Difficult Run to Lynden (Washington) | 2,311.71 mi (3,720.33 km) |
| Difficult Run to Lyndhurst (Ohio) | 283.66 mi (456.51 km) |
| Difficult Run to Lyndon (Kentucky) | 447.17 mi (719.65 km) |
