| Difficult Run to Los Alamos (New Mexico) | 1,595.27 mi (2,567.34 km) |
| Difficult Run to Los Altos (California) | 2,409.65 mi (3,877.96 km) |
| Difficult Run to Los Angeles (California) | 2,284.75 mi (3,676.95 km) |
| Difficult Run to Los Banos (California) | 2,349.51 mi (3,781.17 km) |
| Difficult Run to Los Gatos (California) | 2,405.01 mi (3,870.49 km) |
| Difficult Run to Los Lunas (New Mexico) | 1,644.19 mi (2,646.07 km) |
| Difficult Run to Los Osos (California) | 2,386.03 mi (3,839.95 km) |
| Difficult Run to Loudoun Valley Estates (Virginia) | 9.97 mi (16.05 km) |
| Difficult Run to Louisville (Colorado) | 1,479.16 mi (2,380.48 km) |
| Difficult Run to Louisville (Kentucky) | 451.38 mi (726.42 km) |
| Difficult Run to Lovejoy (Georgia) | 541.35 mi (871.22 km) |
| Difficult Run to Loveland (Colorado) | 1,471.89 mi (2,368.78 km) |
| Difficult Run to Loveland (Ohio) | 372.23 mi (599.05 km) |
| Difficult Run to Loves Park (Illinois) | 654.79 mi (1,053.79 km) |
| Difficult Run to Lovington (New Mexico) | 1,505.87 mi (2,423.46 km) |
