| Difficult Run to Lewiston (Maine) | 515.96 mi (830.36 km) |
| Difficult Run to Lewisville (North Carolina) | 256.28 mi (412.44 km) |
| Difficult Run to Lewisville (Texas) | 1,167.16 mi (1,878.36 km) |
| Difficult Run to Lexington (Kentucky) | 389.14 mi (626.27 km) |
| Difficult Run to Lexington (Nebraska) | 1,192.10 mi (1,918.50 km) |
| Difficult Run to Lexington (North Carolina) | 267.57 mi (430.61 km) |
| Difficult Run to Lexington (South Carolina) | 401.83 mi (646.69 km) |
| Difficult Run to Lexington Park (Maryland) | 66.31 mi (106.72 km) |
| Difficult Run to Liberal (Kansas) | 1,287.20 mi (2,071.55 km) |
| Difficult Run to Liberty (Missouri) | 914.72 mi (1,472.10 km) |
| Difficult Run to Liberty Lake (Washington) | 2,064.00 mi (3,321.68 km) |
| Difficult Run to Liberty Triangle (Florida) | 733.70 mi (1,180.78 km) |
| Difficult Run to Libertyville (Illinois) | 603.73 mi (971.61 km) |
| Difficult Run to Lighthouse Point (Florida) | 886.53 mi (1,426.73 km) |
| Difficult Run to Lilburn (Georgia) | 512.05 mi (824.06 km) |
