| Difficult Run to Largo (Florida) | 821.00 mi (1,321.28 km) |
| Difficult Run to Largo (Maryland) | 27.91 mi (44.91 km) |
| Difficult Run to Larkspur (California) | 2,421.41 mi (3,896.88 km) |
| Difficult Run to Las Cruces (New Mexico) | 1,706.75 mi (2,746.74 km) |
| Difficult Run to Las Vegas (Nevada) | 2,069.88 mi (3,331.14 km) |
| Difficult Run to Las Vegas (New Mexico) | 1,543.71 mi (2,484.36 km) |
| Difficult Run to Latham (New York) | 325.22 mi (523.38 km) |
| Difficult Run to Lathrop (California) | 2,359.97 mi (3,798.00 km) |
| Difficult Run to Lauderdale Lakes (Florida) | 895.23 mi (1,440.73 km) |
| Difficult Run to Lauderhill (Florida) | 895.99 mi (1,441.96 km) |
| Difficult Run to Laurel (Florida) | 863.70 mi (1,389.99 km) |
| Difficult Run to Laurel (Maryland) | 29.26 mi (47.09 km) |
| Difficult Run to Laurel (Mississippi) | 829.76 mi (1,335.38 km) |
| Difficult Run to Laurel (Virginia) | 87.77 mi (141.25 km) |
| Difficult Run to Laurinburg (North Carolina) | 309.42 mi (497.96 km) |
