| Difficult Run to Iselin (New Jersey) | 197.97 mi (318.60 km) |
| Difficult Run to Isla Vista (California) | 2,355.45 mi (3,790.73 km) |
| Difficult Run to Issaquah (Washington) | 2,294.20 mi (3,692.16 km) |
| Difficult Run to Ithaca (New York) | 248.73 mi (400.29 km) |
| Difficult Run to Ives Estates (Florida) | 908.98 mi (1,462.87 km) |
| Difficult Run to Jackson (Michigan) | 436.19 mi (701.99 km) |
| Difficult Run to Jackson (Mississippi) | 852.73 mi (1,372.34 km) |
| Difficult Run to Jackson (Missouri) | 676.36 mi (1,088.50 km) |
| Difficult Run to Jackson (Tennessee) | 669.70 mi (1,077.78 km) |
| Difficult Run to Jackson (Wyoming) | 1,754.39 mi (2,823.41 km) |
| Difficult Run to Jacksonville (Alabama) | 584.95 mi (941.38 km) |
| Difficult Run to Jacksonville (Arkansas) | 861.66 mi (1,386.71 km) |
| Difficult Run to Jacksonville (Florida) | 640.97 mi (1,031.54 km) |
| Difficult Run to Jacksonville (Illinois) | 690.52 mi (1,111.29 km) |
| Difficult Run to Jacksonville (North Carolina) | 288.32 mi (464.00 km) |
