| Difficult Run to Felida (Washington) | 2,332.81 mi (3,754.30 km) |
| Difficult Run to Fenton (Michigan) | 427.88 mi (688.61 km) |
| Difficult Run to Fergus Falls (Minnesota) | 1,076.86 mi (1,733.03 km) |
| Difficult Run to Ferguson (Missouri) | 696.45 mi (1,120.83 km) |
| Difficult Run to Fernandina Beach (Florida) | 615.22 mi (990.10 km) |
| Difficult Run to Ferndale (Maryland) | 43.09 mi (69.34 km) |
| Difficult Run to Ferndale (Michigan) | 390.06 mi (627.74 km) |
| Difficult Run to Ferndale (Washington) | 2,317.83 mi (3,730.18 km) |
| Difficult Run to Fernley (Nevada) | 2,219.35 mi (3,571.70 km) |
| Difficult Run to Ferry Pass (Florida) | 803.90 mi (1,293.74 km) |
| Difficult Run to Festus (Missouri) | 706.71 mi (1,137.33 km) |
| Difficult Run to Fife (Washington) | 2,309.19 mi (3,716.29 km) |
| Difficult Run to Fillmore (California) | 2,305.27 mi (3,709.98 km) |
| Difficult Run to Findlay (Ohio) | 364.46 mi (586.54 km) |
| Difficult Run to Finneytown (Ohio) | 385.04 mi (619.67 km) |
