| Difficult Run to Euless (Texas) | 1,178.21 mi (1,896.14 km) |
| Difficult Run to Eureka (California) | 2,456.79 mi (3,953.82 km) |
| Difficult Run to Eureka (Missouri) | 717.17 mi (1,154.17 km) |
| Difficult Run to Eustis (Florida) | 736.91 mi (1,185.94 km) |
| Difficult Run to Evans (Colorado) | 1,455.24 mi (2,341.98 km) |
| Difficult Run to Evans (Georgia) | 455.16 mi (732.52 km) |
| Difficult Run to Evanston (Illinois) | 585.15 mi (941.71 km) |
| Difficult Run to Evanston (Wyoming) | 1,773.56 mi (2,854.27 km) |
| Difficult Run to Evansville (Indiana) | 554.57 mi (892.49 km) |
| Difficult Run to Everett (Massachusetts) | 409.00 mi (658.23 km) |
| Difficult Run to Everett (Washington) | 2,299.08 mi (3,700.02 km) |
| Difficult Run to Evergreen Park (Illinois) | 578.81 mi (931.51 km) |
| Difficult Run to Ewa Beach (Hawaii) | 4,819.93 mi (7,756.93 km) |
| Difficult Run to Ewa Gentry (Hawaii) | 4,820.28 mi (7,757.49 km) |
| Difficult Run to Excelsior Springs (Missouri) | 904.72 mi (1,456.00 km) |
