| Difficult Run to Enumclaw (Washington) | 2,292.30 mi (3,689.10 km) |
| Difficult Run to Ephrata (Pennsylvania) | 108.05 mi (173.88 km) |
| Difficult Run to Erie (Colorado) | 1,473.18 mi (2,370.85 km) |
| Difficult Run to Erie (Pennsylvania) | 264.27 mi (425.30 km) |
| Difficult Run to Erlanger (Kentucky) | 388.93 mi (625.92 km) |
| Difficult Run to Escanaba (Michigan) | 685.68 mi (1,103.49 km) |
| Difficult Run to Escondido (California) | 2,237.51 mi (3,600.92 km) |
| Difficult Run to Española (New Mexico) | 1,581.44 mi (2,545.07 km) |
| Difficult Run to Essex (Maryland) | 55.73 mi (89.69 km) |
| Difficult Run to Essex Junction (Vermont) | 443.46 mi (713.68 km) |
| Difficult Run to Estelle (Louisiana) | 957.78 mi (1,541.39 km) |
| Difficult Run to Estero (Florida) | 899.53 mi (1,447.65 km) |
| Difficult Run to Euclid (Ohio) | 287.88 mi (463.30 km) |
| Difficult Run to Eufaula (Alabama) | 652.50 mi (1,050.10 km) |
| Difficult Run to Eugene (Oregon) | 2,365.00 mi (3,806.10 km) |
