| Difficult Run to Emeryville (California) | 2,410.86 mi (3,879.90 km) |
| Difficult Run to Emmaus (Pennsylvania) | 149.66 mi (240.85 km) |
| Difficult Run to Emporia (Kansas) | 1,015.68 mi (1,634.59 km) |
| Difficult Run to Encinitas (California) | 2,249.84 mi (3,620.77 km) |
| Difficult Run to Endicott (New York) | 230.90 mi (371.60 km) |
| Difficult Run to Endwell (New York) | 232.90 mi (374.81 km) |
| Difficult Run to Englewood (Colorado) | 1,473.80 mi (2,371.86 km) |
| Difficult Run to Englewood (Florida) | 873.48 mi (1,405.73 km) |
| Difficult Run to Englewood (New Jersey) | 225.55 mi (362.98 km) |
| Difficult Run to Englewood (Ohio) | 377.49 mi (607.51 km) |
| Difficult Run to Enid (Oklahoma) | 1,133.33 mi (1,823.92 km) |
| Difficult Run to Ennis (Texas) | 1,171.81 mi (1,885.84 km) |
| Difficult Run to Ensley (Florida) | 806.90 mi (1,298.58 km) |
| Difficult Run to Enterprise (Alabama) | 709.67 mi (1,142.11 km) |
| Difficult Run to Enterprise (Nevada) | 2,072.37 mi (3,335.16 km) |
