| Difficult Run to Elkhorn (Wisconsin) | 640.08 mi (1,030.10 km) |
| Difficult Run to Elko (Nevada) | 2,025.47 mi (3,259.68 km) |
| Difficult Run to Elkridge (Maryland) | 38.21 mi (61.49 km) |
| Difficult Run to Elkton (Maryland) | 95.08 mi (153.01 km) |
| Difficult Run to Ellensburg (Washington) | 2,224.94 mi (3,580.69 km) |
| Difficult Run to Ellicott City (Maryland) | 37.81 mi (60.85 km) |
| Difficult Run to Elmhurst (Illinois) | 594.22 mi (956.30 km) |
| Difficult Run to Elmira (New York) | 222.36 mi (357.85 km) |
| Difficult Run to Elmont (New York) | 229.78 mi (369.80 km) |
| Difficult Run to Elmwood Park (Illinois) | 588.49 mi (947.09 km) |
| Difficult Run to Elmwood Park (New Jersey) | 220.00 mi (354.06 km) |
| Difficult Run to Elon (North Carolina) | 226.84 mi (365.06 km) |
| Difficult Run to Eloy (Arizona) | 1,953.32 mi (3,143.57 km) |
| Difficult Run to Elwood (New York) | 251.40 mi (404.60 km) |
| Difficult Run to Elyria (Ohio) | 303.92 mi (489.12 km) |
