| Difficult Run to El Sobrante (California) | 2,239.98 mi (3,604.90 km) |
| Difficult Run to Eldersburg (Maryland) | 40.64 mi (65.41 km) |
| Difficult Run to Elfers (Florida) | 800.27 mi (1,287.92 km) |
| Difficult Run to Elgin (Illinois) | 615.77 mi (990.99 km) |
| Difficult Run to Elizabeth (New Jersey) | 207.18 mi (333.43 km) |
| Difficult Run to Elizabeth City (North Carolina) | 190.14 mi (306.00 km) |
| Difficult Run to Elizabethton (Tennessee) | 320.89 mi (516.43 km) |
| Difficult Run to Elizabethtown (Kentucky) | 469.69 mi (755.89 km) |
| Difficult Run to Elizabethtown (Pennsylvania) | 95.23 mi (153.26 km) |
| Difficult Run to Elk City (Oklahoma) | 1,237.03 mi (1,990.80 km) |
| Difficult Run to Elk Grove (California) | 2,352.58 mi (3,786.11 km) |
| Difficult Run to Elk Grove Village (Illinois) | 598.85 mi (963.75 km) |
| Difficult Run to Elk Plain (Washington) | 2,310.45 mi (3,718.30 km) |
| Difficult Run to Elk River (Minnesota) | 940.13 mi (1,512.99 km) |
| Difficult Run to Elkhart (Indiana) | 492.96 mi (793.34 km) |
