| Difficult Run to Eggertsville (New York) | 290.99 mi (468.30 km) |
| Difficult Run to Egypt Lake-Leto (Florida) | 808.28 mi (1,300.80 km) |
| Difficult Run to El Cajon (California) | 2,240.12 mi (3,605.12 km) |
| Difficult Run to El Campo (Texas) | 1,270.06 mi (2,043.97 km) |
| Difficult Run to El Centro (California) | 2,165.21 mi (3,484.56 km) |
| Difficult Run to El Cerrito (California) | 2,409.80 mi (3,878.19 km) |
| Difficult Run to El Dorado (Arkansas) | 939.70 mi (1,512.31 km) |
| Difficult Run to El Dorado (Kansas) | 1,057.83 mi (1,702.42 km) |
| Difficult Run to El Dorado Hills (California) | 2,330.52 mi (3,750.61 km) |
| Difficult Run to El Mirage (Arizona) | 1,970.98 mi (3,171.98 km) |
| Difficult Run to El Monte (California) | 2,265.48 mi (3,645.93 km) |
| Difficult Run to El Paso (Texas) | 1,701.16 mi (2,737.76 km) |
| Difficult Run to El Paso de Robles (California) | 2,369.62 mi (3,813.53 km) |
| Difficult Run to El Reno (Oklahoma) | 1,155.27 mi (1,859.23 km) |
| Difficult Run to El Segundo (California) | 2,289.28 mi (3,684.24 km) |
